Research status of pathogenic genes related to intracranial aneurysms

Intracranial aneurysm, IA, the major diseases that threaten human safety seriously, and is also important diseases leading to subarachnoid hemorrhage (SAH). The incidence rate of SAH in China is about 9.1/10, and the mortality and disability rate is very high. The formation and rupture mechanism of IA is complex, which is caused by the joint action of congenital factors and acquired factors. The prevention and treatment of congenital factors of IA is more important. Zhou et al. Found that the risk of SAH in patients with pedigree IA is 4~7 times higher than that in patients with sporadic IA. 

Gene screening for healthy people can realize early detection, early diagnosis and early treatment before ia rupture, so as to avoid adverse consequences. Ia seriously endangers human health. Environmental factors and polygenic susceptibility factors all affect the pathogenesis of IA. By studying the occurrence and development of IA and actively looking for its genetic risk factors and new pathogenic genes, it is expected to provide research direction for the diagnosis and treatment of IA.

In recent years, the genetic research of IA has attracted more and more attention. Exploring the pathogenic genes related to IA is of great significance to guide the clinical treatment of IA and further implement gene therapy. At the molecular level, IA and angiotensin converting enzyme (ACE), elastin, endothelial glycoprotein, type III collagen (col3), matrix metalloproteinase (MMP), endothelial nitric oxide synthase (eNOS), interleukin (IL) and tumor necrosis factor-α (tumor necrosis factor-α, TNF-α), A review of the clinical relationship between PR4 gene and apolipoprotein 4 gene.

IA is an important cause of spontaneous SAH. Once ruptured, it will seriously threaten human health; At present, there is a lack of early screening indicators, and the specific mechanism of IA formation and development is not clear. Exploring and discovering the related genes of IA is expected to provide new ideas for the screening, prediction, clinical diagnosis, treatment and even prognosis of IA. Screening ia susceptibility genes to assess the risk of IA rupture can provide a basis for early clinical intervention, which has positive practical significance for patients and society.

The pathological mechanism of IA formation and rupture is very complex, which may be the result of the joint action of multiple susceptibility genes. In addition, there are non genetic factors such as hemodynamic factors and acquired factors. At present, the research on each susceptibility gene of IA formation and rupture is still imperfect. It is necessary to explore the correlation between each susceptibility gene and IA formation from the perspective of genetics and pathological mechanism. With the continuous development and improvement of biological genetic engineering and genetic engineering technology, the pathogenic genes of IA will be further improved and clarified in the future, so as to fundamentally treat IA.

 

Cindy