Why people not having a fever long time are more susceptible to cancer

Why are people who dont have a fever for a long time more likely to suffer from cancer?

People who dont have a fever for a long time not only have low immunity, but also are more prone to cancer.

Many people just have a runny nose and cough when they catch a cold, and rarely have a fever.

Are these people at higher risk of cancer than ordinary people?

According to the latest research, fever may make people more resistant to cancer.

The body temperature of normal people is about 37 ℃, because the human brain has a thermoregulatory center. Therefore, no matter how the external environment changes, the heat generation and heat dissipation can be balanced and maintained at a constant temperature. However, when the heat source is generated, the heat production of the body will increase, resulting in the delay of heat dissipation, resulting in the body temperature exceeding the normal range and causing fever.

Heat sources can be divided into exogenous heat sources and endogenous heat sources. Exogenous pyrogens mainly include microbial pathogens, inflammatory exudates, aseptic necrosis and antigen antibody complexes; Endogenous pyrogen mainly includes interleukin, tumor necrosis factor, interferon and other leukocyte pyrogen.

When you have a fever, your body temperature rises, killing most harmful microorganisms, increasing the number of immune cells and improving immunity. Therefore, fever is a self-protection mechanism of the body. So, does this mean that people who do not have a fever for a long time have low immunity? It is not true.

People who do not have a fever for a long time show that the immune system is strong, viruses and bacteria are killed in the bud, and there is no time to trigger the fever mechanism. Another situation is that people who do not have a fever for a long time pay attention to health preservation and have strong physical resistance, so the chance of virus and bacterial invasion is relatively small.

A recent study published in the journal PNAs shows that fever can enhance the mitochondrial quality and metabolic activity of CD8 + effector T cells, improve the mitochondrial translation ability and significantly enhance the anti-tumor ability.

Led by Professor Erika L. Pearce of Max Planck Institute of immunobiology and epigenetics in Germany, this study is of great significance for tumor immunotherapy.

The researchers pointed out that when the body is infected, CD8 + T cells in the body are activated and transformed into active effector T cells. At the same time, effector T cells secrete a large number of cytokines and cytotoxic molecules to inhibit pathogens and play an anti-tumor role.

Therefore, the researchers hypothesized that fever would have a beneficial effect on the metabolic reprogramming of CD8 + effector T cells and change cell function. To test this hypothesis, the researchers conducted cell culture experiments in vitro. At 37 ℃ and 39 ℃, the researchers activated CD8 + T cells in vitro with anti-CD3/CD28. It was found that at 39 ℃, IFN- γ The production of molecules related to glucose metabolism was more than that at 37 ℃, and the activity of mitochondria was also significantly enhanced.

Next, the researchers conducted experiments on mice. By physical heating, the body temperature of mice increased. The results showed that the mitochondrial mass and glucose metabolism related 2-NBDG of mouse te cells were significantly up-regulated, which was consistent with the results of cell culture in vitro.

In general, studies have shown that fever can optimize the metabolic process of CD8 + effector T cells and improve the anti-tumor ability. In the future clinical tumor treatment, appropriately increasing the patients body temperature may be an effective adjuvant treatment.

 

Cindy