The aim of this study was to investigate the effects of Nyuhuang Fuzheng Granule on humoral immune function and antioxidant capacity in rats. Eighty rats were randomly divided into the blank group and the high, medium and low dose groups of Nyuhuang Fuzheng Granule, with 20 rats in each group. The high, medium and low dose groups of Nyuhuang Fuzheng Granule were administered at a dose of 3 g/kg, 2 g/kg and 1 g/kg, respectively, once a day for 14 days, and the blank group was given the same dose of physiological saline. At the end of the experiment, Elisa method was used to detect serum immunoglobulins IgA, IgM, IgG, IL-10 and IL-6 levels and to determine serum malondialdehyde (MDA) levels and peroxidase (POD) and superoxide dismutase (SOD) activity in the rats. The results showed that compared with the blank control group, serum IgG and IL-6 levels increased highly significantly (p < 0.01) and the content of IL-10 was significantly (p < 0.05) raised in the middle dose group. No significant difference was observed in serum SOD and POD activity and MDA content between the Nyuhuang Fuzheng Granule rats and the control group (p > 0.05). These results indicated that Nyuhuang Fuzheng Granule can improve the bodys humoral immune function by increasing the IgG, IL-6 and IL-10 levels in it, and its antioxidant capacity is not obvious.
Keywords
Nyuhuang Fuzheng Granule; rat ; antioxidant capacity; humoral immune function
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