Recombinant Human Defensin,alpha 1 (DEFA1) Protein

  • Cat.No.: AP50130HU

  • Reactivity: Human

To Purchase AP50130HU

100μg 500μg
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Product Details

Species Reactivity Human
Source Prokaryotic expression
Host E. coli
Synonyms DEF1; DEFA2; MRS; DEFA1; DEFA1B
Concentration 1 mg/mL
Form Lyophilized or Liquid
Purity > 90% as determined by SDS-PAGE
Residues P59665
Tag N-terminal His-tag
Purification Affinity purification
Molecular Weight(MW) 9 kDa
Applications Western blotting,ELISA;SDS-PAGE;Antigen;

Product Overview

Defensin, alpha 1 also known as human alpha defensin 1, human neutrophil peptide 1 (HNP-1) or neutrophil defensin 1 is a human protein that is encoded by the DEFA1 gene. Human alpha defensin 1 belongs to the alpha defensin family of antimicrobial peptides. Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. It differs from the defensins, alpha 2 and alpha 3 by only one amino acid.


Reconstitute in PBS or others.


The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.


Store it under sterile conditions at -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -80℃.

Stroage Buffer

Lyophilized from 50mM Tris-HCL,0.5mM EDTA,50mM NaCl,pH 7.4


This product is for research use only, not for diagnostic or therapeutic use.